In this research the effect of using domestic (Multibehcil) and imported (Bioplus B2) probiotic supplements and Avilamycin antibiotics were investigated on performance, parameters of blood lipid and small intestine morphology by a sample of 360 male Ross-308 broilers aging 11 to 42 days-old in a completely randomized design with 6 treatments, 4 replications and 15 chickens per each replicate. Experimental treatments included 1) without additive (control), 2) diets containing 0.1% of commercial bioplus B2 probiotic, 3) diets containing 0.01% of avilamycin antibiotic and treatments 4) to 6) diets containing 0.05%, 1% and 0.15% of Multibehcil, respectively. The results showed that body weight and feed conversion ratio was improved by using bioplus B2 probiotic and antibiotic (P < 0.05). Body weight and feed conversion ratio in birds receiving 0.1% and 0.15% of Multibehcil were not significantly different from birds receiving bioplus probiotic. Feed intake was not affected by the experimental treatments. Humoral immune response and intestinal morphological parameters in birds receiving 0.15% of Multibehcil was not significantly different from the control group and it was statistically equal to the groups receiving bioplus probiotics and antibiotics. The LDL level of blood showed a significant decrease in Bioplus B2, antibiotic and 0.15% of Multibehcil treatments (P < 0.05). In general, the results indicated that using of Multibehcil at the level of 0.15 percent can be a suitable alternative for both Bioplus B2 and Avilamycin during grower and finisher period in broilers.