Reference
Abbasi, B. H. A., Rashid, N., Bilal, R. M., Wadaan, M. A., & Khan, M. F. (2024). Supplementation of Cichorium intybus roots improved the growth performance, immunity response, gut ecology and morphology of broilers chicken Ross308 strain. Journal of King Saud University-Science, 36(8), 103314.https://doi.org/10.1016/j.jksus.2024.103314
Aljumaah, M. R., Alkhulaifi, M. M., Abudabos, A. M., Alabdullatifb, A., El-Mubarak, A. H., Al Suliman, A. R., & Stanley, D. (2020). Organic acid blend supplementation increases butyrate and acetate production in Salmonella enterica serovar Typhimurium challenged broilers. PLoS One, 15(6), 31-47. https://doi.org/10.1371/journal.pone.0232831
Awad, W., Ghareeb, K., & Böhm, J. (2008). Intestinal structure and function of broiler chickens on diets supplemented with a synbiotic containing Enterococcus faecium and oligosaccharides. International Journal of Molecular Sciences, 9(11), 2205-2216.https://doi.org/10.3390/ijms9112205
Dai, D., Qi, G., Wang, J., Zhang, H., Qiu, K., Han, Y., & Wu, S. (2022). Dietary organic acids ameliorate high stocking density stress-induced intestinal inflammation through the restoration of intestinal microbiota in broilers. Journal of Animal Science and Biotechnology, 13(1), 124.https://doi.org/10.1186/s40104-022-00776-2
Dai, D., Qiu, K., Zhang, H. J., Wu, S. G., Han, Y. M., Wu, Y. Y., & Wang, J. (2021). Organic acids as alternatives for antibiotic growth promoters alter the intestinal structure and microbiota and improve the growth performance in broilers. Frontiers in Microbiology, 11, 618144.https://doi.org/10.3389/fmicb.2020.618144
Delfani, N., Daneshyar, M., Farhoomand, P., Alijoo, Y. A., Payvastegan, S., & Najafi, G. (2022). Effects of arginine and guanidinoacetic acid supplementation with or without phenylalanine on performance and ascites susceptibility in cold-stressed broilers fed canola meal-based diet. Journal of Animal Science and Technology, 64(6), 69-95.https://doi.org/10.5187/jast.2022.e68
Delfani, N., Daneshyar, M., Farhoomand, P., Payvastegan, S., Alijoo, Y. A., & Najafi, G. (2024). Attenuating susceptibility to ascites in cold‐stressed broiler chickens fed canola meal‐based diets by supplementing arginine or guanidinoacetic acid, either alone or in combination with phenylalanine. Veterinary Medicine and Science, 10(6), e70011.https://doi.org/10.1002/vms3.70011
Dong, Y., Zheng, Y., Liu, H., Wang, Y., Cui, J., Wu, Y., & Li, J. (2025). Effects of high stocking density on the growth performance, intestinal health and bile salts composition of broiler chickens. Frontiers in Microbiology, 16, 1542059.https://doi.org/10.3389/fmicb.2025.1542059
Dosu, G., Obanla, T. O., Zhang, S., Sang, S., Adetunji, A. O., Fahrenholz, A. C., ... & Fasina, Y. O. (2023). Supplementation of ginger root extract into broiler chicken diet: effects on growth performance and immunocompetence. Poultry Science, 102(10), 102897. https://doi.org/10.1016/j.psj.2023.102897
Evans, L., Brooks, G. C., Anderson, M. G., Campbell, A. M., & Jacobs, L. (2023). Environmental complexity and reduced stocking density promote positive behavioral outcomes in broiler chickens. Animals, 13(13), 2074. https://doi.org/10.3390/ani13132074
Farahat, M., Ibrahim, D., Kishawy, A. T. Y., Abdallah, H. M., Hernandez-Santana, A., & Attia, G. (2021). Effect of cereal type and plant extract addition on the growth performance, intestinal morphology, caecal microflora, and gut barriers gene expression of broiler chickens. Animal, 15(3), 100056. https://doi.org/10.1016/j.animal.2020.100056
Feddes, J. J., Emmanuel, E. J., & Zuidhoft, M. J. (2002). Broiler performance, body weight variance, feed and water intake, and carcass quality at different stocking densities. Poultry Science, 81(6), 774-779. https://doi.org/10.1093/ps/81.6.774
Garcia, V., Catala-Gregori, P., Hernandez, F., Megias, M. D., & Madrid, J. (2007). Effect of formic acid and plant extracts on growth, nutrient digestibility, intestine mucosa morphology, and meat yield of broilers. Journal of Applied Poultry Research, 16(4), 555-562.https://doi.org/10.3382/japr.2006-00116
Gewaily, M. S., El-Khyat, F., Tahoon, A. E., Al-Rasheed, M., Abdo, S. E., Gado, A., & Ismail, M. M. (2023). Cytokines, serological, and histopathological assessment of recombinant vaccination strategies for combatting infectious bursal disease in broiler chickens. Vaccines, 12(1), 27.https://doi.org/10.3390/vaccines12010027
Gholami, M., Chamani, M., Seidavi, A., Sadeghi, A. A., & Aminafschar, M. (2020). Effects of stocking density and environmental conditions on performance, immunity, carcase characteristics, blood constitutes, and economical parameters of cobb 500 strain broiler chickens. Italian Journal of Animal Science, 19(1), 524-535.https://doi.org/10.1080/1828051X.2020.1757522
Guinebretière, M., Warin, L., Moysan, J. P., Méda, B., Mocz, F., Le Bihan-Duval, E., & Mignon-Grasteau, S. (2024). Effects of strain and stocking density on leg health, activity, and use of enrichments in conventional broiler chicken production. Poultry Science, 103(9), 103993.https://doi.org/10.1016/j.psj.2024.103993
Gul, S., Hussain, F., Taj, R., & Ullah, A. (2024). Effect of dietary Moringa oleifera on production performance and gut health in broilers. Journal of Advanced Veterinary and Animal Research, 11(2), 339-356. https://doi.org/10.5455/javar.2024.k782
Guo, Y. J., Wang, Z. Y., Wang, Y. S., Chen, B., Huang, Y. Q., Li, P., ... & Chen, W. (2022). Impact of drinking water supplemented 2-hydroxy-4-methylthiobutyric acid in combination with acidifier on performance, intestinal development, and microflora in broilers. Poultry Science, 101(3), 101661.https://doi.org/10.1016/j.psj.2021.101661
Han, M., Chen, B., Dong, Y., Miao, Z., Su, Y., Liu, C., & Li, J. (2023). Evaluation of liquid organic acids on the performance, chyme pH, nutrient utilization, and gut microbiota in broilers under high stocking density. Animals, 13(2), 257.https://doi.org/10.3390/ani13020257
Hayat, Z., Marij, & Riaz, T. (2025). The dietary inclusion of plant extracts improves growth performance, gut microbiota and blood parameters of broilers: a meta-analysis. Italian Journal of Animal Science, 24(1), 1028-1045. https://doi.org/10.1080/1828051X.2025.2491754
Kamel, N. F., Hady, M. M., Ragaa, N. M., & Mohamed, F. F. (2021). Effect of nucleotides on growth performance, gut health, and some immunological parameters of broiler chicken exposed to high stocking density. Livestock Science, 253, 104703.https://doi.org/10.1016/j.livsci.2021.104703
Khan, R. U., Naz, S., Raziq, F., Qudratullah, Q., Khan, N. A., Laudadio, V., ... & Ragni, M. (2022). Prospects of organic acids as safe alternative to antibiotics in broiler chickens diet. Environmental Science and Pollution Research, 29(22), 32594-32604.https://doi.org/10.1007/s11356-022-19241-8
Kim, J. W., Kim, J. H., & Kil, D. Y. (2015). Dietary organic acids for broiler chickens: a review. Revista Colombiana de Ciencias Pecuarias, 28(2), 109-123.http://dx.doi.org/10.17533/udea.rccp.v28n2a01
Lambert, G. P. (2009). Stress-induced gastrointestinal barrier dysfunction and its inflammatory effects. Journal of Animal Science, 87(14), 101-108. https://doi.org/10.2527/jas.2008-1339
Lesson, S. & Summers, J. D. (2008). Commercial poultry nutrition. 3rd ed. Nottingham: Nottingham University Press.
Li, X. M., Zhang, M. H., Liu, S. M., Feng, J. H., Ma, D. D., Liu, Q. X., & Xing, S. (2019). Effects of stocking density on growth performance, growth regulatory factors, and endocrine hormones in broilers under appropriate environments. Poultry Science, 98(12), 6611-6617.https://doi.org/10.3382/ps/pez505
Liu, S., Wang, K., Lin, S., Zhang, Z., Cheng, M., Hu, S., & Si, H. (2023). Comparison of the effects between tannins extracted from different natural plants on growth performance, antioxidant capacity, immunity, and intestinal flora of broiler chickens. Antioxidants, 12(2), 441.https://doi.org/10.3390/antiox12020441
Magnuson, A. D., Liu, G., Sun, T., Tolba, S. A., Xi, L., Whelan, R., & Lei, X. G. (2020). Supplemental methionine and stocking density affect antioxidant status, fatty acid profiles, and growth performance of broiler chickens. Journal of Animal Science, 98(4), skaa092.https://doi.org/10.1093/jas/skaa092
Mustafa, A. A. & Tayeb, I. T. (2022). The influence of dietary salvia and lavender powders on productive performance, some physiological parameters, and immunity of broiler under stocking density stress. Iraqi Journal of Agricultural Sciences, 53(6), 1280-1288.https://doi.org/10.36103/ijas.v53i6.1642
Obeidat, M. D., Alkhateeb, M. E. M., Jawasreh, K. I., Riley, D. G., & Al Sukhni, I. A. (2024). Herbal extract dietary supplementation effect on growth performance and meat quality in broiler raised under two stocking densities. Scientific Reports, 14(1), 18633.https://doi.org/10.1038/s41598-024-68138-8
Palizdar, M. H., Daylami, M. K., & Pourelmi, M. R. (2017). Effects of high stocking density on growth performance, blood metabolites and immune response of broilers (ROSS 308). Journal of Livestock Science 8, 196-200.
Palizdar, M. H., Pourelmi, M., Mohammadian-Tabrizi, H., & Sepehr, Z. (2016). The impact of Acidifier in the diet of broiler chickens grown in high stocking densities on growth performance, immune system and blood metabolites. Journal of Animal Production, 18(1), 95-106.https://doi.org/10.22059/jap.2016.57147
Pan, H., Bi, J., Hu, H., Huang, Y., Li, A., Zhang, H., & Bai, X. (2025). Chinese herbal medicine improves antioxidant capacity of chicken liver at high stocking density involved gut-liver microbiota axis based on multi-omics technologies. Poultry Science, 104(5), 105015.https://doi.org/10.1016/j.psj.2025.105015
Pelicano, E., Souza, P., & Souza, H. (2005). Intestinal mucosa development in broiler chickens fed natural growth promoters. Brazilian Journal of Poultry Science, 7(3), 221-9.
Rafeeq, M., Bilal, R. M., Batool, F., Yameen, K., Farag, M. R., Madkour, M., & Alagawany, M. (2023). Application of herbs and their derivatives in broiler chickens: a review. World's Poultry Science Journal, 79(1), 95-117.https://doi.org/10.1080/00439339.2022.2151395
Rahman, M. M., Sarker, R. D., & Nooruzzaman, M. (2017). Evaluation of serum antibody titer level against Newcastle disease virus in vaccinated broiler chickens. Annals of Veterinary and Animal Science, 4, 94-98.
Rathnayake, D., Mun, H. S., Dilawar, M. A., Baek, K. S., & Yang, C. J. (2021). Time for a paradigm shift in animal nutrition metabolic pathway: Dietary inclusion of organic acids on the production parameters, nutrient digestibility, and meat quality traits of swine and broilers. Life, 11(6), 476.https://doi.org/10.3390/life11060476
Rodríguez-Yoldi, M. J. (2021). Anti-inflammatory and antioxidant properties of plant extracts. Antioxidants, 10(6), 921.https://doi.org/10.3390/antiox10060921
Saleem, A., Saleem, M., & Akhtar, M. F. (2020). Antioxidant, anti-inflammatory and antiarthritic potential of Moringa oleifera Lam: An ethnomedicinal plant of Moringaceae family. South African Journal of Botany, 128, 246-256.https://doi.org/10.1016/j.sajb.2019.11.023
Salvo Romero, E., Alonso Cotoner, C., Pardo Camacho, C., Casado Bedmar, M., & Vicario, M. (2015). The intestinal barrier function and its involvement in digestive disease. Revista Española de Enfermedades Digestivas, 107(11), 686-96.https://doi.org/10.17235/reed.2015.3846/2015
Selionova, M. I., Trukhachev, V. I., Zagarin, A. Y., Kulikov, E. I., & Belyaeva, N. P. (2025). Effects of Dietary Supplementation Using Phytobiotics with Different Functional Properties on Expression of Immunity Genes, Intestinal Histology, Growth, and Meat Productivity of Broiler Chickens. Veterinary Sciences, 12(4), 302. https://doi.org/10.3390/vetsci12040302
Shynkaruk, T., Long, K., LeBlanc, C., & Schwean-Lardner, K. (2023). Impact of stocking density on the welfare and productivity of broiler chickens reared to 34 d of age. Journal of Applied Poultry Research, 32(2), 100344.https://doi.org/10.1016/j.japr.2023.100344
Sigolo, S., Milis, C., Dousti, M., Jahandideh, E., Jalali, A., Mirzaei, N., & Prandini, A. (2021). Effects of different plant extracts at various dietary levels on growth performance, carcass traits, blood serum parameters, immune response and ileal microflora of Ross broiler chickens. Italian Journal of Animal Science, 20(1), 359-371. https://doi.org/10.1080/1828051X.2021.1883485
Silas, A. F., Ayorinde, A. O., Daisy, E., Mark, S. O., Bolanle, O. O., & Nwakaegh, E. G. (2014). Effect of stocking density and quantitative feed restriction on growth performance, digestibility, haematological characteristics and cost of starting broiler chicks. Journal of Animal Health and Production, 2(4), 60-64.http://dx.doi.org/10.14737/journal.jahp/2014/2.4.60.64
Slifer, Z. M. & Blikslager, A. T. (2020). The integral role of tight junction proteins in the repair of injured intestinal epithelium. International Journal of Molecular Sciences, 21(3), 972.https://doi.org/10.3390/ijms21030972
Sugiharto, S. & Yudiarti, T. (2022). The effect of using acidified turmeric on some productive parameters and intestinal bacterial counts in broilers at high stocking density pens. Journal of Advanced Veterinary and Animal Research, 9(1), 87.https://doi.org/10.5455/javar.2022.i572
Sugiharto, S. (2022). Dietary strategies to alleviate high-stocking-density-induced stress in broiler chickens–a comprehensive review. Archives Animal Breeding, 65(1), 21-36.https://doi.org/10.5194/aab-65-21-2022
Talebi, A., Maham, M., Asri-Rezaei, S., Pournaghi, P., Khorrami, M. S., & Derakhshan, A. (2021). Effects of Nigella sativa on performance, blood profiles, and antibody titer against Newcastle disease in broilers. Evidence‐Based Complementary and Alternative Medicine, 2021(1), 2070375.https://doi.org/10.1155/2021/2070375
Vandenborne, K., De Groef, B., Geelissen, S. M., Kühn, E. R., Darras, V. M., & Van der Geyten, S. (2005). Corticosterone-induced negative feedback mechanisms within the hypothalamo–pituitary–adrenal axis of the chicken. Journal of Endocrinology, 185(3), 383-391.https://doi.org/10.1677/joe.1.05969
Waghmare, S., Gupta, M., Bahiram, K. B., Korde, J. P., Bhat, R., Datar, Y., ... & Kurkure, N. V. (2025). Effects of organic acid blends on the growth performance, intestinal morphology, microbiota, and serum lipid parameters of broiler chickens. Poultry Science, 104(1), 104546. https://doi.org/10.1016/j.psj.2024.104546
Wahed, N. M., Mohammed, A. S., Abomosallam, M., & Fawzy, S. (2024). Economic and Behavioral Benefits of Using Aqueous Plant-mixture Extracts in Broiler Production with High Stocking Density. Alexandria Journal of Veterinary Sciences, 81(1).http://dx.doi.org/10.5455/ajvs.196850
Wang, J., Lu, J., Xie, X., Xiong, J., Huang, N., Wei, H., & Peng, J. (2018). Blend of organic acids and medium chain fatty acids prevents the inflammatory response and intestinal barrier dysfunction in mice challenged with enterohemorrhagic Escherichia coli O157: H7. International Immunopharmacology, 58, 64-71.https://doi.org/10.1016/j.intimp.2018.03.014
Weimer, S. L., Mauromoustakos, A., Karcher, D. M., & Erasmus, M. A. (2020). Differences in performance, body conformation, and welfare of conventional and slow-growing broiler chickens raised at 2 stocking densities. Poultry Science, 99(9), 4398-4407.https://doi.org/10.1016/j.psj.2020.06.009
Xue, F., Shi, L., Li, Y., Ni, A., Ma, H., Sun, Y., & Chen, J. (2020). Effects of replacing dietary Aureomycin with a combination of plant essential oils on production performance and gastrointestinal health of broilers. Poultry Science, 99(9), 4521-4529.https://doi.org/10.1016/j.psj.2020.05.030
Yadav, S., & Jha, R. (2019). Strategies to modulate the intestinal microbiota and their effects on nutrient utilization, performance, and health of poultry. Journal of Animal Science and Biotechnology, 10(1), 2-14. https://doi.org/10.1186/s40104-018-0310-9
Zabir, M., Miah, M. A., Alam, M., Bhuiyan, M. E. J., Haque, M. I., Sujan, K. M., & Mustari, A. (2021). Impacts of stocking density rates on welfare, growth, and hemato-biochemical profile in broiler chickens. Journal of Advanced Veterinary and Animal Research, 8(4), 642.https://doi.org/10.5455/javar.2021.h556
Zhang, R., Sun, J., Wang, Y., Yu, H., Wang, S., & Feng, X. (2025). Ameliorative effect of phenolic compound-pterostilbene on corticosterone-induced hepatic lipid metabolic disorder in broilers. The Journal of Nutritional Biochemistry, 137, 109822. https://doi.org/10.1016/j.jnutbio.2024.109822