Document Type : Research Paper
Authors
Department of Animal Science, University of Tehran
Abstract
The effect of Pioglitazone and Curcumin on lipid metabolism and plasma metabolites of broiler breeder was investigated as a completely randomized design with three treatments and four replications by using of 60 hens at age 45 weeks during 10 weeks. Experimental treatments including: 1) Control (basal diet), 2) Adding 20 mg/bird/day Pioglitazone to diet and, 3) Adding 20 mg/bird/day Curcumin to diet. At the end of experiment, blood samples were collected, and birds were slaughtered. The results showed that hens receiving Pioglitazone or Curcumin had higher egg production and shell thickness when compared with control group (p<0.05). However, the yolk and egg weight of birds in the control group were higher than two another groups (p<0.05). Plasma concentrations of glucose, triglycerides and cholesterol were lower in hens feeding Pioglitazone or Curcumin than control (p<0.05). Liver and abdominal fat weight and adipocyte diameter were lower in birds receiving Pioglitazone or Curcumin (p<0.05). Based on current results, dietary supplementation of Pioglitazone or Curcumin, through lowering plasma lipids and subsequently positive influence on abdominal fat tissue and liver, could improve production in broiler breeders.
Keywords
2. Belfort R, Harrison SA, Brown K, Darland C and Finch J. (2006) A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. The New England Journal of Medicine 355(22): 2297-2307.
3. Bennion NL, Warren DC (1933) Some factors affecting egg size in the domestic fowl. Poultry Science 12(6): 362-367.
4. Betteridge DJ (2007) Effects of pioglitazone on lipid and lipoprotein metabolism. Diabetes and Obesity Metabolism 9(5): 640-647.
5. Boden G, Cheung P, Mozzoli M, Fried SK (2003) Effect of thiazolidinediones on glucose and fatty acid metabolism in patients with type 2 diabetes. Metabolism 52(6): 753-759.
6. Chen SE, McMurtry JP, Walzem RL (2006) Overfeeding-induced ovarian dysfunction in broiler breeder hens is associated with lipotoxicity. Poultry Science 85(1): 70-81.
7. Chen W-L, Wei H-W, Chiu W-Z, Kang C-H, Lin T-H. (2011) Metformin regulates hepatic lipid metabolism through activating AMPactivated protein kinase and inducing ATGL in laying hens. European Journal of Pharmacology 671(1): 107-112.
8. Ghorbani Z, Hekmatdoost A, Mirmiran P (2014) Anti-hyperglycemic and insulin sensitizer effects of turmeric and its principle constituent curcumin. International journal of endocrinology and metabolism 12(4):e18081.
9. Clark M, Thomaseth K, Dirikolu L, Ferguson DC, Hoenig M (2014) Effects of pioglitazone on insulin sensitivity and serum lipids in obese cats. Journal of Veterinary Internal Medicine 28(1): 166-174.
10. Glueck CJ, Moreira A, Goldenberg N, Sieve L, Wang P (2003) Pioglitazone and metformin in obese women with polycystic ovary syndrome not optimally responsive to metformin. Human Reproduction 18(8): 1618-1625.
11. Hussian M, Arain AQ, Chiragh S (2016) Pioglitazone improves serum lipid profile in diet induced hyperlipidaemic non diabetic rats. Journal of Pakistan Medical Association 66(10): 1286-1290.
12. Jacob A, Wu R, Zhou M, Wang P (2007) Mechanism of the anti-inflammatory effect of curcumin: PPAR-gamma activation. PPAR research 89(3): 60-69.
13. Ji B, Ernest B, Gooding JR, Das S, Saxton AM, et al. (2012) Transcriptomic and metabolomic profiling of chicken adipose tissue in response to insulin neutralization and fasting. BMC Genomics 13(1): 441-449.
14. Kuroda M, Mimaki Y, Nishiyama T, Mae T, Kishida H, Tsukagawa M, Takahashi K, Kawada T, Nakagawa K, Kitahara M (2005) Hypoglycemic effects of turmeric (Curcuma longa L. rhizomes) on genetically diabetic KK-Ay mice. Biological & pharmaceutical bulletin 28(5):937-939.
15. Larsen TM, Toubro S, Astrup A (2003) PPAR gamma agonists in the treatment of type II diabetes: is increased fatness commensurate with long-term efficacy? International Journal of Obesity and Related Metabolic Disorders 27(2): 147-161.
16. Leeson S, Summers JD (2000) Broiler Breeder Production: Nottingham University Press pp 184.
17. Pan YE, Liu ZC, Chang CJ, Huang YF, Lai CY. (2014) Feed restriction ameliorates metabolic dysregulation and improves reproductive performance of meat-type country chickens. Animal Reproduction Science 151(3): 229-236.
18. Richards MP, Proszkowiec-Weglarz M (2007) Mechanisms regulating feed intake, energy expenditure, and body weight in poultry. Poultry Science 86(7): 1478-1490.
19. Roque L, Soares MC (1994) Effects of eggshell quality and broiler breeder age on hatchability. Poultry Science 73(12): 1838-1845.
20. Siriwardhana N, Kalupahana NS, Cekanova M, LeMieux M, Greer B. (2013) Modulation of adipose tissue inflammation by bioactive food compounds. Journal of Nutritional Biochemistry 24(4): 613-623.
21. Smith U (2001) Pioglitazone: mechanism of action. International Journal of Clinical Practice Suppl (121): 13-18.
22. Sun K, Kusminski CM, Scherer PE (2011) Adipose tissue remodeling and obesity. The Journal of Clinical Investigation 121(6): 2094- 2101.
23. Yki-Jarvinen H (2004) Thiazolidinediones. The New England Journal of Medicine 351(11): 1106-1118.
24. Yousefi AR, Kohram H, Zare Shahneh A, Zamiri MJ, Fouladi-Nashta AA (2016) Effects of dietary supplementation of pioglitazone on metabolism, milk yield, and reproductive performance in transition dairy cows. Theriogenology 85(9): 1540-1548.
25. Zhang J, Hu Z, Lu C, Bai K, Zhang L, Wang T (2015) Effect of various levels of dietary curcumin on meat quality and antioxidant profile of breast muscle in broilers. Journal of agricultural and food chemistry 63(15): 3880- 3886.
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