Document Type : Research Paper


Department of Animal Science, Faculty of Agricultural Science & Engineering, University of Tehran, Karaj, Iran


The insulin resistance and glucose, insulin, IGF-1 metabolism (somatotropic axis performance) were investigated in cows to receive (4 g yeast/d/head) (Probio-Sacc®, BioChem, GmbH, Germany) or not receive live yeast supplement from 21 d before expected date of calving under the hot months of summer (THI = 82). Two groups of 6 periparturient Holstein cows were fed a diet without or with 4 g yeast/d/head (15*109 CFU/g) starting 21 d prepartum through 8 weeks postpartum to investigate the changes of blood concentrations of glucose, insulin, IGF-1 and glucose tolerance test (GTT). On d 60 postpartum, greater blood levels of glucose, insulin and insulin-like growth factor I were found in cows receiving yeast supplement than those receiving no yeast (P<0/05). Probiotic had not significant effect on GTT test. Overall, it appears that Probiotics would beneficially improve the blood concentrations of glucose, insulin, IGF-1 in day 60 postpartum (on DFS day) and improve somatotropic axis of dairy cows during the heat stress. Probiosac probiotic had positive effects on somatotropic axis and animal performance. It’s can be a good solution to increase dairy cow’s performance in heat stress condition.


1.      Butler WR (2003) Energy balance relationships with follicular development, ovulation and fertility in postpartum dairy cows. Livestock. Production. Science. 83: 211-218.
2.     Bonczek R, YoungC, Wheaton J and Miller K (1999) Responses of somatotropin, insulin, prolactin, and thyroxine to selection for milk yield in Holsteins. Journal of Dairy Science. 71: 2470-2479.
3.      Dehghan-Banadaky M, Ebrahimi M, Motameny R, and Heidari SR (2012) Effects of live yeast supplementation on mid-lactation dairy cow's performances, milk composition, rumen digestion and plasma metabolites during hot season. Journal of Applied Animal Research. 23: 1-6.
4.      Djoković R, Šamanc H, Ilić Z and Kurćubić V (2009) Blood glucose, insulin and inorganic phosphorus in healthy and ketotic dairy cows after intravenous infusion of glucose solution. Journal Acta VeterinariaBrunensis. 78: 449-453.
5.     Drackley JK, Overton TR and Douglas GN (2001) Adaptations of glucose and long-chain fatty acid metabolism in liver of dairy cows during the periparturient period. Journal of Dairy Science. 84: 100-112.
6.     Drackley JK, Dann HM, Douglas GN, Janovick Guretzky NA, Litherland NB, Underwood JP and Loor JJ (2005) Physiological and pathological adaptations in dairy cows that may increase susceptibility to periparturient diseases and disorders. Italian Journal of Animal Science. 4: 323-344.
7.     Garnsworthy PC, Sinclair KD and Webb R (2008) Integration of physiological mechanisms that influence fertility in dairy cows. International Journal of Animal Anatomy and Physiology. 2: 1144-1152.
8.     Gong JG, Lee WJ, Garnsworthy PC and Webb R (2002) Effect of dietary induced increases in circulating insulin concentrations during the early postpartum period on reproductive function in dairy cows.  Animal Reproduction Science. 123: 419-427.
9.     Ibrahim RM, Whelan SJ, Pierce KM, Campion DP, Gath VP and Mulligan FJ (2012) Effect of timing of post-partum introduction to pasture and supplementation with Saccharomyces cerevisiae on milk production, metabolic status, energy balance and some reproductive parameters in early lactation dairy cows. Journal of Animal physiology and Animal Nutrition. 97: 105-114.
10.   Kawashima C, Fukihara S, Maeda M, Kaneko E, Montoya CA and Matsui M (2007) Relationship between metabolic hormones and ovulation of dominant follicle during the first follicular wave post-partum in high-producing dairy cows.Animal Reproduction Science. 133: 155-163.
11.   Morimoto S, Cerbon MA, Alvarez-Alvarez A, Romero-Navarro G and Díaz-Sánchez V (2001) Insulin gene expression pattern in rat pancreas during the estrous cycle. Life Sciences. 68: 2979-2985.
12.   Opsomer G, Wensing T, Laevens H, Coryn M and de Kruif A (1999) Insulin resistance: The link between metabolic disorders and cystic ovarian disease in high yielding dairy cows? Animal ReproductionScience. 56: 211-222.
13.   Rigout SS, Lemosquet JE, van Eys JW and Rulquin H (2002) Duodenal glucose increases glucose fluxes and lactose synthesis in grass silage-fed dairy cows. Journal of Dairy Science. 85: 595-606.