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Immune response of broilers to vitamin C and coenzyme Q10 under cold stress condition

Document Type : Research Paper

Authors

1 Ph.D. Student, Department of Animal Science, Faculty of Agriculture, University of Zanjan, and Instructor of Agricultural and Natural Resources of Zanjan, Zanjan, Iran

2 Assistant Professor, Department of Animal Science, Faculty of Agriculture, University of Zanjan, Zanjan, Iran

3 Assistant Professor of Animal Science Research Institute, Karaj, Iran

Abstract

This experiment was conducted to determine the effect of vitamin C (VC) and coenzyme Q10 (CoQ10) on
immunity response of broilers in cold stress condition using 500 male chicks in a completely randomized
design with 5 treatments and five replicates. Treatments were: positive control (PC, normal conditions
growth without antioxidants), negative control (NC, cold stress without antioxidants), cold stress + VC
(300 mg/kg diet), cold stress + CoQ10 (40 mg/kg diet) and cold stress + VC + CoQ10 at above mentioned
doses. To induce cold stress, from day 15 until end, temperature fixed at 15oC. Vaccine titers, humeral
and cellular immune response and relative immune organs weight were studied. Results showed that cold
stress decreased relative spleen weight but there was no significant difference between treatments.
Relative weight of bursa was increased in cold stress condition (P<0.01) and using antioxidant especially
CoQ10 decreased it (P<0.05). Lymphocyte percent decreased in cold stress (P<0.05). Improved cellmediated
immune response to subcutaneous injection of phytohemagglutinin and proliferation of T
lymphocyte in vitro were observed (P<0.05). In conclusion, use of antioxidants VC and CoQ10 in the cold
stress condition improved immune system activity and decreased mortality

Keywords

References
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Animal Production
Volume 15, Issue 1 - Serial Number 1
July 2014
Pages 45-53
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