Hossein Emrani; Rasoult Vaes Torshizi
Volume 19, Issue 1 , May 2017, , Pages 33-45
Abstract
Ascites Syndrome is a costly metabolic disorder that has been linked to intense selection on growth rate and low feed conversion ratio in broilers. This Syndrome has become one of the most frequent causes of mortality within the broiler industry and leads to substantial economic losses and reduced animal ...
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Ascites Syndrome is a costly metabolic disorder that has been linked to intense selection on growth rate and low feed conversion ratio in broilers. This Syndrome has become one of the most frequent causes of mortality within the broiler industry and leads to substantial economic losses and reduced animal welfare. To identify genes and genomic regions associated with Ascites Syndrome, genome wide association study was performed by the chicken 60K SNP panel on 101 birds from a F2 chicken population derived from the reciprocal cross between Arian broiler Line and Azerbaijan native fowls. Genomic best linear unbiased prediction procedure was used to calculate associations between each SNP and ascite related traits. Several SNPsfor the ratio of right ventricular to total ventricular, an indicator for Ascites syndrome, reached the suggestive threshold (8.25×10-5) on chromosome 7. Two SNPs detected within CCDC141 and OSBPL6 genes were previously reported for human heart disorder. There are a large number of genes in this region (12745561-14602723) on chicken chromosome 7 that are related to hypertrophic cardiomyopathy, heart rate and human heart disorder. Selection for ascites resistance in broiler chicken using these findings could accelerate the genetic progress.
ali javanrouh aliabad; Ali akbar masoudi; alireza ehsani
Volume 18, Issue 4 , December 2016, , Pages 697-709
Abstract
In order to identify loci and genes associated with meat quality traits, genome-wide association study (GWAS) were conducted in a F2 population derived from a reciprocal cross between Azerbaijan native chickens and Aryan broiler line by using Illumnia 60 K Chicken SNP Bead chip. For each bird, a total ...
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In order to identify loci and genes associated with meat quality traits, genome-wide association study (GWAS) were conducted in a F2 population derived from a reciprocal cross between Azerbaijan native chickens and Aryan broiler line by using Illumnia 60 K Chicken SNP Bead chip. For each bird, a total 6 traits including water holding capacity, meat color lightness (L*), redness (a*), yellowness (b*), shear force and ultimate pH were measured. The SNPs that were associated with meat quality traits were identified using both GLM and compressed mixed linear models (CMLM). A total of 36 SNPs were associated with meat quality traits in the genome–wide significance and suggestive levels, that 3 SNPs were significantly associated with meat color yellowness through CMLM model and 18 SNPs were suggestively associated with meat color yellowness, ultimate pH, water holding capacity and shear force through GLM model. The identified candidate genes have molecular functions related to meat quality traits. So, these candidate genes can be applied in the chicken breeding scheme.